B-Cell Linker anticorps (AA 171-356)

N° du produit ABIN1838325

Cet anticorps anti-B-Cell Linker est un anticorps Lapin Polyclonal détectant B-Cell Linker dans WB. Adapté pour Humain.

Aperçu rapide pour B-Cell Linker anticorps (AA 171-356) (ABIN1838325)

Antigène: B-Cell Linker (BLNK)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp B-Cell Linker est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-B-Cell Linker anticorps

Épitope: AA 171-356

Specificité: BLNK (B cell linker protein) is an adaptor molecule that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). This activation leads to an increase in the tyrosine phosphorylation of a number of proteins due to activation of nonreceptor protein tyrosine kinases (PTK) including Syk, which is responsible for the tyrosine phosphorylation of BLNK. BLNK is cytosolic protein identified as two phosphoproteins migrating at 68 and 70 kD in SDS/PAGE (alternatively spliced forms of human BLNK). Mapping of the tyrosine residues in BLNK reveal three tyrosines that bind PLC-gamma2, and two tyrosines that bind the Tec family kinase Btk, the Vav nucleotide exchange factor and the adaptor Nck.

Purification: Purified

Immunogène: A fusion protein representing amino acids 171-356 of human BLNK.

Type of Immunogen: Fusion protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Détails sur B-Cell Linker

Antigène: B-Cell Linker (BLNK)

Autre désignation: BLNK

Sujet: Name/Gene ID: BLNK
Family: Signal Transduction

Synonyms: BLNK, AGM4, BLNK-S, B-cell activation, B-cell linker protein, B cell linker protein, Bca, Cytoplasmic adapter protein, LY57, SLP-65, SLP65, B-cell linker, BASH

ID gène: 29760

UniProt: Q8WV28

Pathways: BCR Signaling